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Propoxyphene is a centrally acting narcotic analgesic agent. Equimolar doses of propoxyphene hydrochloride or napsylate provide similar plasma concentrations. Following administration of 65, 130, or 195 mg of propoxyphene hydrochloride, the bioavailability of propoxyphene is equivalent to that of 100, 200, or 300 mg respectively of propoxyphene napsylate. Peak plasma generic darvocet concentrations of propoxyphene are reached in 2 to 2 1/2 hours. After a 100-mg oral dose of propoxyphene napsylate, peak plasma levels of 0.05 to 0.1 ?g/mL are achieved. As shown in Figure 1, the napsylate salt tends to be absorbed more slowly than the hydrochloride. At or near therapeutic doses, this absorption difference is small generic darvocet when compared with that among subjects and among doses.

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These darvocet side effects are not considered serious but are certainly annoying for those experiencing them. The most frequently reported side effects include dizziness, sedation, nausea, vomiting constipation, abdominal pain, skin rashes, lightheadedness, headache, weakness, hallucinations, and minor visual disturbances. If these side effects occur and concern you, please contact your doctor. Signs of a possible allergic reaction are rash, swelling and difficulty breathing. These symptoms should be reported immediately.

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What special precautions should I follow?

Before taking propoxyphene, tell your doctor and pharmacist if you are allergic to propoxyphene or any other drugs. tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially other pain relievers; anticoagulants ('blood-thinners') such as warfarin (Coumadin); antidepressants; antihistamines; medications for cough, cold, generic darvocet or allergies; muscle relaxants; sedatives; seizure medications; sleeping pills; tranquilizers; and vitamins. tell your doctor if you have or have ever had liver or kidney disease, or a history of alcoholism. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking propoxyphene, call your doctor. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking propoxyphene. you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you. remember that alcohol can add to the drowsiness caused by this drug.


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